Regenerative medicine refers to the process of replacing, renewing, or engineering human cells, organs, proteins, and other tissues to restore function and homeostasis in the body. One key component of regenerative medicine involves stem cell replacement strategies that require the use of real stem cells.
Stem cells are our bodies’ undifferentiated cells with the capacity to change into any type of healthy cell including, but not limited to, skin, bone, heart, and muscle. They replicate substantially more than normal somatic cells and thus functionally support our healing processes. However, as we age, so do our stem cells, meaning those already found in our bodies become less effective over time. Because of the limitations of aged stem cells, the ReGen® Series uses young, healthy stem cells from umbilical cords to deliver the highest quality and most effective treatment.
Over 20 peer-reviewed clinical and case studies demonstrate a strong, direct correlation between the application of mesenchymal stem cells (MSCs) and improving overall joint function by regenerating tissue and reducing pain.
Stem cell therapy is an effective method of treatment for fractures. Various studies found a statistically significant difference in healing time between patients who participated in stem cell therapy compared to those using more traditional methods. One specific trial achieved 75% union over a 12-week time period, while another reports 88% union over a 4-month time period in patients with non-union fractures.
Regenerative medicine therapies utilize the anti-inflammatory properties of MSCs to alleviate inflammation-related osteoarthritis (OA) pain. In a 2011 study, doctors injected patients suffering from severe OA pain with MSCs and, compared to the control group, found they were able to walk longer and climb a greater number of stairs after treatment. Researchers followed up with these same patients five years later and discovered that while improvements decreased, the arthritic knees previously injected with MSCs were still functioning above their baseline. Many similar studies additionally support a strong correlation between stem cell therapy and treating arthritic conditions.
In addition to bone and joint related maladies, stem cell therapy can also be used to treat different types of cardiovascular disease, such as coronary heart disease, hypertension, stroke, congestive heart failure, and more. Because of their inherent ability to transform into any type of somatic cell, scientists are discovering how to rebuild and replace damaged heart muscle tissue through stem cell treatments. One 2012 clinical study observed a significant, positive correlation between stem cell therapy and increased cardiothoracic functional capacity.
Stem cell therapy could be an excellent, minimally invasive treatment option for patients with lupus, rheumatoid arthritis, multiple sclerosis, and other autoimmune diseases by helping the body achieve a more favorable TH1/TH2 balance as well as increasing Treg cell numbers. Clinical studies on over 100 participants diagnosed with either lupus or rheumatoid arthritis found a significant positive correlation between the use of umbilical cord MSCs and overall condition. In relation to autoimmune diseases, treatment typically involves a combination of strategically removing problematic cells and restoring functional cells through the administration of MSCs. One clinical trial reports achieving stable disease remission for 12 to 18 months in lupus patients. Another study involving the treatment of a patient with an autoimmune inner ear disease recovered normal hearing in one ear and moderate hearing in the other.
Parkinson’s disease develops when the brain produces less dopamine over time, thus losing the ability to control bodily movements and developing tremors. Among their many capabilities, studies show MSCs can also be differentiated into dopamine secretory cells that, over time, reduce the tremors characteristic of the disease. Studies report encouraging results when testing this treatment method: nearly half of the participants displayed steady improvement over 10 to 36 months.
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